Loxiglumide

Name: Loxiglumide
Brand: Tocris Bioscience
SKU: 3036

Tocris Bioscience, part of Bio-Techne | Catalog # 3036

COA / SDS

CCK1 antagonist; active in vivo

Key Product Details

Description:	CCK1 antagonist; active in vivo
Alternative Names:	CR 1505
Chemical Name:	4-[(3,4-Dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	461.38

View Full Technical Details for Loxiglumide

Technical Data
Citations

Biological Activity for Loxiglumide

Loxiglumide is a CCK1 antagonist. Suppresses CCK-induced proliferation of acinar cells. Inhibits pancreatic secretion of digestive enzymes. Active in vivo.

Compound Libraries for Loxiglumide

Loxiglumide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Loxiglumide

M. Wt	461.38
Formula	C₂₁H₃₀Cl₂N₂O₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	107097-80-3
PubChem ID	60182
InChi Key	QNQZBKQEIFTHFZ-UHFFFAOYSA-N
Smiles	O=C(NC(CCC(O)=O)C(N(CCCOC)CCCCC)=O)C1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Loxiglumide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.14	100
	ethanol	46.14	100

Preparing Stock Solutions for Loxiglumide

The following data is based on the product molecular weight 461.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.84 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for Loxiglumide

References are publications that support the biological activity of the product.

Kanemitsu Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 2006 PMID: 16552340
Nakano S Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis. Pancreas 1995 PMID: 7542770
Makovec New glutamic and aspartic derivatives with potent CCK-antagonistic activity. Eur. J. Med.Chem.