LP 922056

Name: LP 922056
Brand: Tocris Bioscience
SKU: 6691

Tocris Bioscience, part of Bio-Techne | Catalog # 6691

Citations (3)

COA / SDS

Notum inhibitor; activates Wnt signaling

Key Product Details

Description:	Notum inhibitor; activates Wnt signaling
Chemical Name:	2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	300.78

View Full Technical Details for LP 922056

Technical Data
Citations

Biological Activity for LP 922056

LP 922056 is a notum pectinacetylesterase inhibitor. LP 922056 activates wnt signaling in vitro (EC₅₀ values are 21 nM in human and 55 nM in mouse cell-based assay). It increases cortical bone thickness in mouse model of bone growth. LP 922056 also inhibits growth of Apc-mutant cell lines and proliferation of intestinal adenomas in vivo.

Compound Libraries for LP 922056

LP 922056 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for LP 922056

M. Wt	300.78
Formula	C₁₁H₉ClN₂O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1365060-22-5
PubChem ID	56932967
InChi Key	LJYRIWUQISYYHA-UHFFFAOYSA-N
Smiles	OC(CSC1=C2SC(Cl)=C(C2=NC=N1)C3CC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LP 922056

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.08	100

Preparing Stock Solutions for LP 922056

The following data is based on the product molecular weight 300.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.62 mL	33.25 mL
5 mM	0.66 mL	3.32 mL	6.65 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for LP 922056

References are publications that support the biological activity of the product.

Brommage NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 PMID: 30622831
Flanagan NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 2021 PMID: 34079124
Tarver Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 2016 PMID: 26897593