LP 99

Name: LP 99
Brand: Tocris Bioscience
SKU: 5496

Tocris Bioscience, part of Bio-Techne | Catalog # 5496

COA / SDS

Selective BRD7 and BRD9 inhibitor

Key Product Details

Description:	Selective BRD7 and BRD9 inhibitor
Chemical Name:	N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	516.05

View Full Technical Details for LP 99

Technical Data
Citations

Biological Activity for LP 99

LP 99 is a selective BRD7 and BRD9 inhibitor (K_d values are 99 and 909 nM, respectively) that exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). LP 99 inhibits interactions with histones H3.3 and H4 at low micromolar concentrations, and decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells, in vitro. A negative control for LP 99, ent-LP 99 (Cat.No. 5497), is also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LP 99 probe summary on the SGC website.

Compound Libraries for LP 99

LP 99 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LP 99 is reviewed on the chemical probes website.

Technical Data for LP 99

M. Wt	516.05
Formula	C₂₆H₃₀ClN₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1808951-93-0
PubChem ID	91827372
InChi Key	LVDRREOUMKACNJ-BKMJKUGQSA-N
Smiles	CC(C(C=CC(N1[C@@H]([C@H](CCC1=O)NS(=O)(CC(C)C)=O)C2=CC=C(C=C2)Cl)=C3)=C3N4C)=CC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LP 99

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.6	100
	ethanol	51.6	100

Preparing Stock Solutions for LP 99

The following data is based on the product molecular weight 516.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.69 mL	19.38 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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Reconstitution Calculator

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References for LP 99

References are publications that support the biological activity of the product.

Clark LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor. Angew.Chem.Int.Ed.Engl. 2015 PMID: 25864491