LY 2087101

Name: LY 2087101
Brand: Tocris Bioscience
SKU: 4141

Tocris Bioscience, part of Bio-Techne | Catalog # 4141

Citations (2)

COA / SDS

Allosteric potentiator of α7, α4β2 and α4β4 nAChRs

Key Product Details

Description:	Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
Chemical Name:	[2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Purity:	≥98% (HPLC)
Molecular Weight:	318.39

View Full Technical Details for LY 2087101

Technical Data
Citations

Biological Activity for LY 2087101

LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.

Compound Libraries for LY 2087101

LY 2087101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 2087101

M. Wt	318.39
Formula	C₁₅H₁₁FN₂OS₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	913186-74-0
PubChem ID	11964458
InChi Key	PEAMDZVDNYENPN-UHFFFAOYSA-N
Smiles	O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2087101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.84	100
	ethanol	3.18	10

Preparing Stock Solutions for LY 2087101

The following data is based on the product molecular weight 318.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.70 mL	31.41 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for LY 2087101

References are publications that support the biological activity of the product.

Young Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 1879106
Broad Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 2006 PMID: 16738207