LY 2183240

Name: LY 2183240
Brand: Tocris Bioscience
SKU: 2452

Tocris Bioscience, part of Bio-Techne | Catalog # 2452

COA / SDS

Highly potent anandamide uptake inhibitor; also inhibits FAAH

Discontinued Product

2452 has been discontinued. View all Cannabinoid Transporter Inhibitors products.

Key Product Details

Description:	Highly potent anandamide uptake inhibitor; also inhibits FAAH
Chemical Name:	5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	307.35

View Full Technical Details for LY 2183240

Technical Data
Citations

Biological Activity for LY 2183240

LY 2183240 is a novel and highly potent blocker of anandamide uptake (IC₅₀ = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC₅₀ = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

Licensing Information

Sold under license from Eli Lilly and Company

Technical Data for LY 2183240

M. Wt	307.35
Formula	C₁₇H₁₇N₅O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	874902-19-9
PubChem ID	11507802
InChi Key	GZNIYOXWFCDBBJ-UHFFFAOYSA-N
Smiles	CN(C)C(=O)N1N=NN=C1CC1=CC=C(C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 2183240

References are publications that support the biological activity of the product.

Alexander and Cravat The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J.Am.Chem.Soc. 2006 PMID: 16866524
Moore Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc.Natl.Acad.Sci.USA
Dickason-Chesterfield Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol.Neurobiol. 2006 PMID: 16736384