LY 225910

Name: LY 225910
Brand: Tocris Bioscience
SKU: 1018

Tocris Bioscience, part of Bio-Techne | Catalog # 1018

Citations (13)

COA / SDS

Potent CCK2 antagonist

Key Product Details

Description:	Potent CCK₂ antagonist
Chemical Name:	2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
Molecular Weight:	502.41

View Full Technical Details for LY 225910

Technical Data
Citations

Biological Activity for LY 225910

LY 225910 is a potent CCK₂ receptor antagonist (IC₅₀ = 9.3 nM for inhibition of ¹²⁵I-labeled CCK-8 sulfate binding at mouse brain membranes).

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data for LY 225910

M. Wt	502.41
Formula	C₂₇H₂₄BrN₃O₂
Storage	Desiccate at -20°C
CAS Number	133040-77-4
PubChem ID	4355450
InChi Key	KUECXUACQOYKNB-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=CC(=C1)N1C(CCC2=CNC3=CC=C(Br)C=C23)=NC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 225910

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for LY 225910

The following data is based on the product molecular weight 502.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.95 mL	19.90 mL
5 mM	0.40 mL	1.99 mL	3.98 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for LY 225910

References are publications that support the biological activity of the product.

Yu Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 1991 PMID: 2016728
Suman-Chauhan The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [³H]PD140376. Regul.Pept. 1996 PMID: 8876034