LY 2365109 hydrochloride

Name: LY 2365109 hydrochloride
Brand: Tocris Bioscience
SKU: 3397

Tocris Bioscience, part of Bio-Techne | Catalog # 3397

COA / SDS

Potent and selective GlyT1 inhibitor

Key Product Details

Description:	Potent and selective GlyT1 inhibitor
Chemical Name:	N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	421.91

View Full Technical Details for LY 2365109 hydrochloride

Technical Data
Citations

Biological Activity for LY 2365109 hydrochloride

LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor (IC₅₀ values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.

Technical Data for LY 2365109 hydrochloride

M. Wt	421.91
Formula	C₂₂H₂₇NO₅.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1779796-27-8
PubChem ID	56972229
InChi Key	ZQVOAGQZHDAFRM-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=C(OCCN(C)CC(O)=O)C=CC(C2=CC(OCO3)=C3C=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2365109 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.19	100
	ethanol	21.1	50

Preparing Stock Solutions for LY 2365109 hydrochloride

The following data is based on the product molecular weight 421.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.85 mL	23.70 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for LY 2365109 hydrochloride

References are publications that support the biological activity of the product.

Perry Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 2008 PMID: 18602930