M 084 hydrochloride

Name: M 084 hydrochloride
Brand: Tocris Bioscience
SKU: 5807

Tocris Bioscience, part of Bio-Techne | Catalog # 5807

Citations (2)

COA / SDS

TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic

Key Product Details

Description:	TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic
Chemical Name:	N-Butyl-1H-benzimidazol-2-amine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	225.72

View Full Technical Details for M 084 hydrochloride

Technical Data
Citations

Biological Activity for M 084 hydrochloride

M 084 hydrochloride is a TRPC4/5 channel blocker (IC₅₀ values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Technical Data for M 084 hydrochloride

M. Wt	225.72
Formula	C₁₁H₁₅N₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1992047-63-8
PubChem ID	121513894
InChi Key	DMLSYUAQEOLJQC-UHFFFAOYSA-N
Smiles	CCCCNC1=NC2=CC=CC=C2N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M 084 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	22.57	100
	DMSO	22.57	100

Preparing Stock Solutions for M 084 hydrochloride

The following data is based on the product molecular weight 225.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.43 mL	22.15 mL	44.30 mL
5 mM	0.89 mL	4.43 mL	8.86 mL
10 mM	0.44 mL	2.22 mL	4.43 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

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References for M 084 hydrochloride

References are publications that support the biological activity of the product.

Yang Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 2015 PMID: 26317356
Zhu Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 2015 PMID: 25816897