MDL 100907

Name: MDL 100907
Brand: Tocris Bioscience
SKU: 4173

Tocris Bioscience, part of Bio-Techne | Catalog # 4173

Citations (25)

COA / SDS

Potent and selective 5-HT2A antagonist

Key Product Details

Description:	Potent and selective 5-HT_2A antagonist
Alternative Names:	Volinanserin
Chemical Name:	(R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	373.46

View Full Technical Details for MDL 100907

Technical Data
Citations

Biological Activity for MDL 100907

MDL 100907 is a potent and selective 5-HT_2A receptor antagonist (K_i = 0.36 nM, IC₅₀ = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT_2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.

Technical Data for MDL 100907

M. Wt	373.46
Formula	C₂₂H₂₈FNO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	139290-65-6
PubChem ID	5311271
InChi Key	HXTGXYRHXAGCFP-OAQYLSRUSA-N
Smiles	FC(C=C3)=CC=C3CCN(CC2)CCC2[C@@H](O)C1=C(OC)C(OC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MDL 100907

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	18.67	50
	DMSO	37.35	100

Preparing Stock Solutions for MDL 100907

The following data is based on the product molecular weight 373.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for MDL 100907

References are publications that support the biological activity of the product.

Sorensen Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J.Pharmacol.Exp.Ther. 1993 PMID: 8102646
Ardayfio The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant dr J.Pharmacol.Exp.Ther. 2008 PMID: 18772320
Kehne Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J.Pharmacol. 1996 PMID: 8627580