MDL 11,939

Name: MDL 11,939
Brand: Tocris Bioscience
SKU: 0870
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0870

(1)

Citations (35)

COA / SDS

5-HT2A antagonist

Key Product Details

Description:	5-HT_2A antagonist
Chemical Name:	α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Purity:	≥99% (HPLC)
Molecular Weight:	295.42

View Full Technical Details for MDL 11,939

Technical Data
Citations / Reviews (1)

Biological Activity for MDL 11,939

MDL 11,939 is an orally active 5-HT_2A receptor antagonist; displays selectivity for 5-HT_2A receptors over 5-HT_2C receptors (K_i values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT_2A, human 5-HT_2A, rabbit 5-HT_2C and human 5-HT_2C receptors respectively).

Technical Data for MDL 11,939

M. Wt	295.42
Formula	C₂₀H₂₅NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	107703-78-6
PubChem ID	71781
InChi Key	AXNGJCOYCMDPQG-UHFFFAOYSA-N
Smiles	OC(C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MDL 11,939

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	14.77	50
	DMSO	14.77	50

Preparing Stock Solutions for MDL 11,939

The following data is based on the product molecular weight 295.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.77 mL	33.85 mL	67.70 mL
2.5 mM	1.35 mL	6.77 mL	13.54 mL
5 mM	0.68 mL	3.39 mL	6.77 mL
25 mM	0.14 mL	0.68 mL	1.35 mL

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References for MDL 11,939

References are publications that support the biological activity of the product.

Dudley Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT₂ receptors. Drug Dev.Res.
Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Aloyo and Harvey Antagonist binding at 5-HT_2A and 5-HT_2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur.J.Pharmacol. 2000 PMID: 11020478