Mecamylamine hydrochloride

Name: Mecamylamine hydrochloride
Brand: Tocris Bioscience
SKU: 2843

Tocris Bioscience, part of Bio-Techne | Catalog # 2843

Citations (74)

COA / SDS

Non-competitive nAChR antagonist

Key Product Details

Description:	Non-competitive nAChR antagonist
Chemical Name:	(1R,2S,4S)-rel-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Molecular Weight:	203.75

View Full Technical Details for Mecamylamine hydrochloride

Technical Data
Citations

Biological Activity for Mecamylamine hydrochloride

Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Technical Data for Mecamylamine hydrochloride

M. Wt	203.75
Formula	C₁₁H₂₁N.HCl
Storage	Desiccate at RT
CAS Number	110691-49-1
PubChem ID	13221
InChi Key	LRJARFKQBBVCIV-FDYABGJLSA-N
Smiles	C[C@]1(NC)C(C)(C)[C@@H]2CC[C@H]1C2.Cl.C[C@@]1(NC)C(C)(C)[C@H]2CC[C@@H]1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mecamylamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.37	100
	DMSO	20.37	100

Preparing Stock Solutions for Mecamylamine hydrochloride

The following data is based on the product molecular weight 203.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.91 mL	24.54 mL	49.08 mL
5 mM	0.98 mL	4.91 mL	9.82 mL
10 mM	0.49 mL	2.45 mL	4.91 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

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Reconstitution Calculator

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References for Mecamylamine hydrochloride

References are publications that support the biological activity of the product.

Rabenstein The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol.
Ostroumov Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 2007 PMID: 17938901