Meclizine dihydrochloride

Name: Meclizine dihydrochloride
Brand: Tocris Bioscience
SKU: 4245

Tocris Bioscience, part of Bio-Techne | Catalog # 4245

Citations (1)

COA / SDS

Human pregnane X receptor agonist; H1 antagonist

Key Product Details

Description:	Human pregnane X receptor agonist; H₁ antagonist
Alternative Names:	Meclozine
Chemical Name:	1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	463.87

View Full Technical Details for Meclizine dihydrochloride

Technical Data
Citations

Biological Activity for Meclizine dihydrochloride

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H₁ receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Compound Libraries for Meclizine dihydrochloride

Meclizine dihydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Meclizine dihydrochloride

M. Wt	463.87
Formula	C₂₅H₂₇ClN₂.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1104-22-9
PubChem ID	64713
InChi Key	VCTHNOIYJIXQLV-UHFFFAOYSA-N
Smiles	CC1=CC(CN(CC4)CCN4C(C3=CC=C(Cl)C=C3)C2=CC=CC=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Meclizine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.19	50

Preparing Stock Solutions for Meclizine dihydrochloride

The following data is based on the product molecular weight 463.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.31 mL	21.56 mL	43.12 mL
2.5 mM	0.86 mL	4.31 mL	8.62 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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References for Meclizine dihydrochloride

References are publications that support the biological activity of the product.

Oosterveen Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem Cell Reports 2021 PMID: 34678205
Gohil Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 2010 PMID: 20977989
Lau Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 2011 PMID: 21131266
Parada The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 2001 PMID: 11182255