Meclizine dihydrochloride

Name: Meclizine dihydrochloride
Brand: Tocris Bioscience
SKU: 4245

Tocris Bioscience, part of Bio-Techne | Catalog # 4245

Citations (1)

COA / SDS

Human pregnane X receptor agonist; H1 antagonist

Key Product Details

Chemical Name:	1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Purity:	≥99%
Molecular Weight:	463.87 kDa

View Full Technical Details for Meclizine dihydrochloride

Technical Data
Citations

Biological Activity for Meclizine dihydrochloride

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H₁ receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Technical Data for Meclizine dihydrochloride

M. Wt	463.87 kDa
Formula	C₂₅H₂₇ClN₂.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	1104-22-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Meclizine dihydrochloride

Solubility

Soluble Soluble to 50 mM in DMSO

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References for Meclizine dihydrochloride

References are publications that support the biological activity of the product.

Parada et al. The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience, 2001;102:937 PMID: 11182255
Gohil et al. Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet., 2010;20:294 PMID: 20977989
Lau et al. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther., 2011;336:816 PMID: 21131266