Medetomidine hydrochloride

Name: Medetomidine hydrochloride
Brand: Tocris Bioscience
SKU: 5160

Tocris Bioscience, part of Bio-Techne | Catalog # 5160

Citations (5)

COA / SDS

Potent and highly selective α2 agonist

Key Product Details

Chemical Name:	4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity:	≥99%

View Full Technical Details for Medetomidine hydrochloride

Technical Data
Citations

Biological Activity for Medetomidine hydrochloride

Medetomidine hydrochloride is a potent, highly selective α₂-adrenoceptor agonist (K_i values are 1.08 and 1750 nM for α₂- and α₁-adrenoceptors respectively). Displays greater selectivity over α₁-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD₂ = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Active Isomer also available.

Technical Data for Medetomidine hydrochloride

Formula	C₁₃H₁₆N₂.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	86347-15-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Medetomidine hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Medetomidine hydrochloride

References are publications that support the biological activity of the product.

Savola et al. Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol., 1986;6:275 PMID: 2880852
Virtanen et al. Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol., 1988;150:9 PMID: 2900154
Scheinin et al. Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat., 1989;13:635 PMID: 2571177

Medetomidine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5160

Key Product Details

Biological Activity for Medetomidine hydrochloride

Technical Data for Medetomidine hydrochloride

Solubility for Medetomidine hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Medetomidine hydrochloride

Product Documents for Medetomidine hydrochloride

COA

Certificate of Analysis

SDS

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