Melanotan II

Name: Melanotan II
Brand: Tocris Bioscience
SKU: 2566

Tocris Bioscience, part of Bio-Techne | Catalog # 2566

Citations (14)

COA / SDS

High affinity melanocortin receptor agonist

Key Product Details

Description:	High affinity melanocortin receptor agonist
Alternative Names:	MT-II
Purity:	≥95% (HPLC)
Molecular Weight:	1024.19

View Full Technical Details for Melanotan II

Technical Data
Citations

Biological Activity for Melanotan II

Melanotan II is a high affinity melanocortin receptor agonist (K_i values are 0.67, 6.6, 34 and 46 nM for MC₁, MC₄, MC₃ and MC₅ receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Technical Data for Melanotan II

M. Wt	1024.19
Formula	C₅₀H₆₉N₁₅O₉
Single Letter Sequence	XDHFRWK (Modifications: X = Nle & N-terminal Ac, Asp-2 = β-Asp, Phe-4 = D-Phe, Lys-7 = ε-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	121062-08-6
PubChem ID	92432
InChi Key	JDKLPDJLXHXHNV-MFVUMRCOSA-N
Smiles	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Melanotan II

Solubility

Soluble to 0.7mg/ml in water

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References for Melanotan II

References are publications that support the biological activity of the product.

Ter Laak The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur.J.Pharmacol. 2003 PMID: 12591111
Wikberg Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 1999 PMID: 10443584
Martin Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 2002 PMID: 12409007