Mesopram

Name: Mesopram
Brand: Tocris Bioscience
SKU: 3053

Tocris Bioscience, part of Bio-Techne | Catalog # 3053

COA / SDS

Orally active PDE4 inhibitor

Key Product Details

Description:	Orally active PDE4 inhibitor
Chemical Name:	(R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone
Purity:	≥98% (HPLC)
Molecular Weight:	265.31

View Full Technical Details for Mesopram

Technical Data
Citations

Biological Activity for Mesopram

Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.

Technical Data for Mesopram

M. Wt	265.31
Formula	C₁₄H₁₉NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	189940-24-7
PubChem ID	449190
InChi Key	PCCPERGCFKIYIS-AWEZNQCLSA-N
Smiles	O=C1O[C@@](C2=CC(OCCC)=C(OC)C=C2)(C)CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mesopram

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.53	100
	ethanol	26.53	100

Preparing Stock Solutions for Mesopram

The following data is based on the product molecular weight 265.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.85 mL	37.69 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.88 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Molarity Calculator

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Reconstitution Calculator

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References for Mesopram

References are publications that support the biological activity of the product.

Loher The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 2003 PMID: 12606674
McKenna Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 2005 PMID: 15448112
Dinter The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 2000 PMID: 10900347