Methoxyluteolin

Name: Methoxyluteolin
Brand: Tocris Bioscience
SKU: 7320

Tocris Bioscience, part of Bio-Techne | Catalog # 7320

COA / SDS

Inhibitor of pro-inflammatory mediator release from mast cells

Key Product Details

Description:	Inhibitor of pro-inflammatory mediator release from mast cells
Chemical Name:	2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	342.35

View Full Technical Details for Methoxyluteolin

Technical Data
Citations

Biological Activity for Methoxyluteolin

Methoxyluteolin inhibits release of pro-inflammatory mediators from mast cells and decreases gene expression and release of TNF, VEGF and IL-8/CXCL8. The product also significantly inhibits IL-33 stimulated expression and release of CCL5 and CCL2. Methoxyluteolin pretreatment of LAD2 mast cells decreases gene expression of TNF, CXCL8 and VEGF in response to neurotensin or substance P via mTOR activation.

Technical Data for Methoxyluteolin

M. Wt	342.35
Formula	C₁₉H₁₈O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	855-97-0
PubChem ID	631170
InChi Key	CLXVBVLQKLQNRQ-UHFFFAOYSA-N
Smiles	O=C1C=C(OC2=CC(OC)=CC(OC)=C12)C=3C=CC(OC)=C(OC)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methoxyluteolin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.85	20

Preparing Stock Solutions for Methoxyluteolin

The following data is based on the product molecular weight 342.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.02 mL	146.05 mL
1 mM	2.92 mL	14.60 mL	29.21 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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References for Methoxyluteolin

References are publications that support the biological activity of the product.

Taracanova Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin. Proc.Nat.Acad.Sci. USA 2018 PMID: 30232261
Weng The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J.Allergy Clin.Immunol. 2015 PMID: 25498791
Patel and Theoharides Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J.Pharmacol.Exp.Ther. 2017 PMID: 28404689
Abubakr Bawazeer and Theoharides IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur.J.Pharmacol. 2019 PMID: 31669588