Mevastatin

Name: Mevastatin
Brand: Tocris Bioscience
SKU: 1526

Tocris Bioscience, part of Bio-Techne | Catalog # 1526

Citations (9)

COA / SDS

HMG-CoA reductase inhibitor

Key Product Details

Description:	HMG-CoA reductase inhibitor
Alternative Names:	Compactin
Chemical Name:	(2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate
Purity:	≥98% (HPLC)
Molecular Weight:	390.52

View Full Technical Details for Mevastatin

Technical Data
Citations

Biological Activity for Mevastatin

Mevastatin is an inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data for Mevastatin

M. Wt	390.52
Formula	C₂₃H₃₄O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	73573-88-3
PubChem ID	64715
InChi Key	AJLFOPYRIVGYMJ-INTXDZFKSA-N
Smiles	[H][C@@]12C(C=C[C@H](C)[C@@]([H])2CC[C@@]3([H])OC(C[C@]([H])(O)C3)=O)=CCC[C@@H]1OC([C@@H](C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mevastatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	9.76	25 with gentle warming
	DMSO	19.53	50 with gentle warming

Preparing Stock Solutions for Mevastatin

The following data is based on the product molecular weight 390.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.12 mL	25.61 mL	51.21 mL
2.5 mM	1.02 mL	5.12 mL	10.24 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References for Mevastatin

References are publications that support the biological activity of the product.

Cohen Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density lipoprotein-receptor activity in the human hepatoma cell line Hep G2. Biochem.J. 1984 PMID: 6089762
Wachtershauser HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 2001 PMID: 11408350
Amin-Hanjani Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 2001 PMID: 11283400