MI 2 (MALT1 inhibitor)

Name: MI 2 (MALT1 inhibitor)
Brand: Tocris Bioscience
SKU: 4848

Tocris Bioscience, part of Bio-Techne | Catalog # 4848

(1)

Citations (1)

COA / SDS

MALT1 inhibitor

Key Product Details

Chemical Name:	2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for MI 2 (MALT1 inhibitor)

MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC₅₀ = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Technical Data for MI 2 (MALT1 inhibitor)

Formula	C₁₉H₁₇Cl₃N₄O₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	1047953-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MI 2 (MALT1 inhibitor)

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for MI 2 (MALT1 inhibitor)

References are publications that support the biological activity of the product.

Fontan et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell, 2012;22:812 PMID: 23238016

MI 2 (MALT1 inhibitor)

Tocris Bioscience, part of Bio-Techne | Catalog # 4848

Key Product Details

Biological Activity for MI 2 (MALT1 inhibitor)

Technical Data for MI 2 (MALT1 inhibitor)

Solubility for MI 2 (MALT1 inhibitor)

Dilution Calculator

Reconstitution Calculator

References for MI 2 (MALT1 inhibitor)

Product Documents for MI 2 (MALT1 inhibitor)

COA

Certificate of Analysis

SDS

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