MI 2 (MALT1 inhibitor)

Name: MI 2 (MALT1 inhibitor)
Brand: Tocris Bioscience
SKU: 4848
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4848

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Citations (1)

COA / SDS

MALT1 inhibitor

Key Product Details

Description:	MALT1 inhibitor
Chemical Name:	2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	455.72

View Full Technical Details for MI 2 (MALT1 inhibitor)

Technical Data
Citations / Reviews (1)

Biological Activity for MI 2 (MALT1 inhibitor)

MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC₅₀ = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Technical Data for MI 2 (MALT1 inhibitor)

M. Wt	455.72
Formula	C₁₉H₁₇Cl₃N₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1047953-91-2
PubChem ID	45942672
InChi Key	TWJGQZBSEMDPQP-UHFFFAOYSA-N
Smiles	O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MI 2 (MALT1 inhibitor)

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.57	100
	ethanol	9.11	20

Preparing Stock Solutions for MI 2 (MALT1 inhibitor)

The following data is based on the product molecular weight 455.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.97 mL	21.94 mL
5 mM	0.44 mL	2.19 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for MI 2 (MALT1 inhibitor)

References are publications that support the biological activity of the product.

Fontan MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012 PMID: 23238016