(-)-Cytisine

Name: (-)-Cytisine
Brand: Tocris Bioscience
SKU: 1390

Tocris Bioscience, part of Bio-Techne | Catalog # 1390

Citations (12)

COA / SDS

Potent and selective neuronal nAChRagonist

Key Product Details

Description:	Potent and selective neuronal nAChRagonist
Chemical Name:	(1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity:	≥99% (HPLC)
Molecular Weight:	190.24

View Full Technical Details for (-)-Cytisine

Technical Data
Citations

Biological Activity for (-)-Cytisine

(-)-Cytisine is a potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.

Technical Data for (-)-Cytisine

M. Wt	190.24
Formula	C₁₁H₁₄N₂O
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	485-35-8
PubChem ID	10235
InChi Key	ANJTVLIZGCUXLD-DTWKUNHWSA-N
Smiles	O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Cytisine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for (-)-Cytisine

The following data is based on the product molecular weight 190.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.26 mL	26.28 mL	52.57 mL
5 mM	1.05 mL	5.26 mL	10.51 mL
10 mM	0.53 mL	2.63 mL	5.26 mL
50 mM	0.11 mL	0.53 mL	1.05 mL

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Reconstitution Calculator

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References for (-)-Cytisine

References are publications that support the biological activity of the product.

Papke Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β₂ subunit. Mol.Pharmacol. 1994 PMID: 8302273
Reavill Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 1990 PMID: 2385332
Happe Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [³H]cytisine. Neuroscience 1994 PMID: 7870314