(-)-Nicotine ditartrate

Name: (-)-Nicotine ditartrate
Brand: Tocris Bioscience
SKU: 3546

Tocris Bioscience, part of Bio-Techne | Catalog # 3546

Citations (21)

COA / SDS

Prototypical nAChR agonist

Key Product Details

Description:	Prototypical nAChR agonist
Chemical Name:	(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Purity:	≥99% (HPLC)
Molecular Weight:	462.41

View Full Technical Details for (-)-Nicotine ditartrate

Technical Data
Citations

Biological Activity for (-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (K_i values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data for (-)-Nicotine ditartrate

M. Wt	462.41
Formula	C₁₀H₁₄N₂.2C₄H₆O₆
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	65-31-6
PubChem ID	11957628
InChi Key	RFEJUZJILGIRHQ-OMDKHLBYSA-N
Smiles	CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Nicotine ditartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.24	100
	DMSO	34.68	75

Preparing Stock Solutions for (-)-Nicotine ditartrate

The following data is based on the product molecular weight 462.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.63 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for (-)-Nicotine ditartrate

References are publications that support the biological activity of the product.

Xiao Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 1998 PMID: 9687574
Mayhan Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 1999 PMID: 10385481
Donnelly-Roberts ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 1998 PMID: 9580626

Product Documents for (-)-Nicotine ditartrate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Nicotine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov