(-)-Quinpirole hydrochloride

Name: (-)-Quinpirole hydrochloride
Brand: Tocris Bioscience
SKU: 1061
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1061

(2)

Citations (129)

COA / SDS

Selective D2-like agonist

Key Product Details

Description:	Selective D₂-like agonist
Chemical Name:	(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	255.79

View Full Technical Details for (-)-Quinpirole hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for (-)-Quinpirole hydrochloride

(-)-Quinpirole hydrochloride is a selective dopamine D₂ receptor agonist (K_i values are 4.8, ~24, ~30 and 1900 nM at D₂, D₃, D₄ and D₁ receptors respectively).

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries for (-)-Quinpirole hydrochloride

(-)-Quinpirole hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (-)-Quinpirole hydrochloride

M. Wt	255.79
Formula	C₁₃H₂₁N₃.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	85798-08-9
PubChem ID	55397
InChi Key	HJHVRVJTYPKTHX-HTMVYDOJSA-N
Smiles	Cl.[H][C@]12CCCN(CCC)[C@]1([H])CC1=CNN=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Quinpirole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.58	100
	DMSO	6.39	25

Preparing Stock Solutions for (-)-Quinpirole hydrochloride

The following data is based on the product molecular weight 255.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.91 mL	19.55 mL	39.09 mL
5 mM	0.78 mL	3.91 mL	7.82 mL
10 mM	0.39 mL	1.95 mL	3.91 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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Reconstitution Calculator

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References for (-)-Quinpirole hydrochloride

References are publications that support the biological activity of the product.

Seeman and Van Tol DA receptor pharmacology. Trends Pharmacol.Sci. 1994 PMID: 7940991
Sullivan Effects of quinpirole on central DA systems in sensitized and non-sensitized rats. Neuroscience 1998 PMID: 9483561
Levant Modulation of [³H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 1996 PMID: 8764345