Mitoxantrone dihydrochloride

Name: Mitoxantrone dihydrochloride
Brand: Tocris Bioscience
SKU: 4250

Tocris Bioscience, part of Bio-Techne | Catalog # 4250

(1)

Citations (2)

COA / SDS

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

Discontinued Product

4250 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Chemical Name:	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Purity:	≥98%

View Full Technical Details for Mitoxantrone dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Mitoxantrone dihydrochloride

Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC₅₀ = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC₅₀= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Technical Data for Mitoxantrone dihydrochloride

Formula	C₂₂H₂₈N₄O₆.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	70476-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mitoxantrone dihydrochloride

Solubility

Soluble Soluble to 5 mM in water and to 75 mM in DMSO

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References for Mitoxantrone dihydrochloride

References are publications that support the biological activity of the product.

Burkhart et al. Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol.Cancer Res., 2013;11:901 PMID: 23696131
Scott and Figgit Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs., 2004;18:379 PMID: 15089110
Crespi et al. Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm., 1986;136:521 PMID: 3010982
Wan et al. A new target for an old drug: identifying mitoxan. as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem., 2013;56:2619 PMID: 23442188

Product Documents for Mitoxantrone dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov