MK 212 hydrochloride

Name: MK 212 hydrochloride
Brand: Tocris Bioscience
SKU: 0941

Tocris Bioscience, part of Bio-Techne | Catalog # 0941

Citations (3)

COA / SDS

5-HT2C agonist

Key Product Details

Description:	5-HT_2C agonist
Chemical Name:	6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	235.12

View Full Technical Details for MK 212 hydrochloride

Technical Data
Citations

Biological Activity for MK 212 hydrochloride

MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT_2C over 5-HT_2A (IC₅₀ values are 0.028 and 0.42 μM for human 5-HT_2C and 5-HT_2A receptors expressed in HEK293 cells respectively).

Technical Data for MK 212 hydrochloride

M. Wt	235.12
Formula	C₈H₁₁ClN₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	61655-58-1
PubChem ID	198421
InChi Key	PFIZGLUIYAZQFU-UHFFFAOYSA-N
Smiles	ClC1=CN=CC(N2CCNCC2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK 212 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.76	50 with gentle warming

Preparing Stock Solutions for MK 212 hydrochloride

The following data is based on the product molecular weight 235.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.51 mL	42.53 mL	85.06 mL
2.5 mM	1.70 mL	8.51 mL	17.01 mL
5 mM	0.85 mL	4.25 mL	8.51 mL
25 mM	0.17 mL	0.85 mL	1.70 mL

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References for MK 212 hydrochloride

References are publications that support the biological activity of the product.

Hemrick-Luecke and Fuller Involvement of 5-HT_2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212. Eur.J.Pharmacol. 1996 PMID: 8891601
Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Conn and Sanders-Bush Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT₂ and 5-HT_1C) receptors. J.Pharmacol.Exp.Ther. 1987 PMID: 3039120