MK 386

Name: MK 386
Brand: Tocris Bioscience
SKU: 5842

Tocris Bioscience, part of Bio-Techne | Catalog # 5842

COA / SDS

Potent, selective human type 1 5α-reductase inhibitor

Key Product Details

Description:	Potent, selective human type 1 5α-reductase inhibitor
Chemical Name:	(4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	415.69

View Full Technical Details for MK 386

Technical Data
Citations

Biological Activity for MK 386

MK 386 is a potent and selective human type 1 5α-reductase inhibitor (5αR1, IC₅₀ = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC₅₀ = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.

Technical Data for MK 386

M. Wt	415.69
Formula	C₂₈H₄₉NO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	158493-17-5
PubChem ID	178013
InChi Key	XUTZDXHKQDPUMA-UHFFFAOYSA-N
Smiles	[H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK 386

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.57	100

Preparing Stock Solutions for MK 386

The following data is based on the product molecular weight 415.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.03 mL	24.06 mL
5 mM	0.48 mL	2.41 mL	4.81 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for MK 386

References are publications that support the biological activity of the product.

Bakshi 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J.Med.Chem. 1994 PMID: 7966146
Schwartz MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J.Clin.Endocrinol.Metab. 1997 PMID: 9141518