ML 141

Name: ML 141
Brand: Tocris Bioscience
SKU: 4266

Tocris Bioscience, part of Bio-Techne | Catalog # 4266

Citations (72)

COA / SDS

Selective Cdc42 Rho family inhibitor

Key Product Details

Chemical Name:	4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity:	≥99%
Molecular Weight:	407.49 kDa

View Full Technical Details for ML 141

Technical Data
Citations

Biological Activity for ML 141

ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC₅₀ = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Technical Data for ML 141

M. Wt	407.49 kDa
Formula	C₂₂H₂₁N₃O₃S
Storage	Store at +4°C
Purity	≥99%
CAS Number	71203-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 141

Solubility

Soluble Soluble to 100 mM in DMSO

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References for ML 141

References are publications that support the biological activity of the product.

Cruz-Orengo L, Daniels B, Dorsey D, Basak S, Grajales-Reyes J, McCandless E, Piccio L, Schmidt R, Cross A, Crosby S, Klein R Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. J Clin Invest, 2014;124(6):2571-84. 2014 PMID: 24812668
F Weeber, A Becher, T Seibold, T Seufferlei, T Eiseler Concerted regulation of actin polymerization during constitutive secretion by Cortactin and PKD2 J. Cell. Sci., 2019;0(0):. 2019 PMID: 31727638
Sakurai T, Woolls M, Jin S, Murakami M, Simons M Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS ONE, 2014;9(6):e90736. 2014 PMID: 24603875
Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H Endophilin marks and controls a clathrin-independent endocytic pathway. Nature, 2015;517(7535):460-5. 2015 PMID: 25517094
M Pontremoli, M Brioschi, R Baetta, S Ghilardi, C Banfi Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells Sci Rep, 2018;8(1):16671. 2018 PMID: 30420710
Hong et al. Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem., 2013;:Epub PMID: 23382385
Surviladze et al. A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program, 2010;:NBK5196 PMID: 21433396