ML 141

Name: ML 141
Brand: Tocris Bioscience
SKU: 4266

Tocris Bioscience, part of Bio-Techne | Catalog # 4266

Citations (72)

COA / SDS

Selective Cdc42 Rho family inhibitor

Key Product Details

Description:	Selective Cdc42 Rho family inhibitor
Alternative Names:	CID 2950007
Chemical Name:	4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	407.49

View Full Technical Details for ML 141

Technical Data
Citations

Biological Activity for ML 141

ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC₅₀ = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Compound Libraries for ML 141

ML 141 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 141

M. Wt	407.49
Formula	C₂₂H₂₁N₃O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	71203-35-5
PubChem ID	2950007
InChi Key	QBNZBMVRFYREHK-UHFFFAOYSA-N
Smiles	COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 141

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.75	100

Preparing Stock Solutions for ML 141

The following data is based on the product molecular weight 407.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.27 mL	24.54 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for ML 141

References are publications that support the biological activity of the product.

Hong Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. 2013 PMID: 23382385
Surviladze A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program 2010 PMID: 21433396