ML 162

Name: ML 162
Brand: Tocris Bioscience
SKU: 7821

Tocris Bioscience, part of Bio-Techne | Catalog # 7821

Citations (5)

COA / SDS

Inhibits glutathione peroxidase (GPX4); induces ferroptosis

Key Product Details

Chemical Name:	2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
Purity:	≥98%

View Full Technical Details for ML 162

Technical Data
Citations

Biological Activity for ML 162

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀ = 25 and 578 nM for HRAS^G12V-expressing and wild-type BJ fibroblasts, respectively).

Technical Data for ML 162

Formula	C₂₃H₂₂Cl₂N₂O₃S
Storage	Store at -20°C
Purity	≥98%
CAS Number	1035072-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 162

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for ML 162

References are publications that support the biological activity of the product.

Weïwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett., 2012;22:1822 PMID: 22297109

ML 162

Tocris Bioscience, part of Bio-Techne | Catalog # 7821

Key Product Details

Biological Activity for ML 162

Technical Data for ML 162

Solubility for ML 162

Dilution Calculator

Reconstitution Calculator

References for ML 162

Product Documents for ML 162

COA

Certificate of Analysis

SDS

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