ML 193

Tocris Bioscience, part of Bio-Techne | Catalog # 4860

(1)

Citations (9)

COA / SDS

Potent, selective GPR55 antagonist

Key Product Details

Description:	Potent, selective GPR55 antagonist
Alternative Names:	CID 1261822
Chemical Name:	N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	527.59

View Full Technical Details for ML 193

Technical Data
Citations / Reviews (1)

Biological Activity for ML 193

ML 193 is a selective GPR55 antagonist (IC₅₀ = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB₁, GPR35 and CB₂, respectively. Inhibits ERK signaling in vitro.

Technical Data for ML 193

M. Wt	527.59
Formula	C₂₈H₂₅N₅O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	713121-80-3
PubChem ID	1261822
InChi Key	HTSLEZOTMYUPLU-UHFFFAOYSA-N
Smiles	CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 193

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.76	100

Preparing Stock Solutions for ML 193

The following data is based on the product molecular weight 527.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.90 mL	3.79 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for ML 193

References are publications that support the biological activity of the product.

Kotsikorou Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 2013 PMID: 24274581
Heynen-Genel Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 22091481