ML 204

Name: ML 204
Brand: Tocris Bioscience
SKU: 4732

Tocris Bioscience, part of Bio-Techne | Catalog # 4732

Citations (16)

COA / SDS

Selective TRPC4 inhibitor

Key Product Details

Description:	Selective TRPC4 inhibitor
Chemical Name:	4-Methyl-2-(1-piperidinyl)quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	226.32

View Full Technical Details for ML 204

Technical Data
Citations

Biological Activity for ML 204

ML 204 is a blocker of TRPC4 channels (IC₅₀ values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Compound Libraries for ML 204

ML 204 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 204

M. Wt	226.32
Formula	C₁₅H₁₈N₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	5465-86-1
PubChem ID	230710
InChi Key	USYRQXDHKXGTCK-UHFFFAOYSA-N
Smiles	CC2=CC(N3CCCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 204

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.63	100
	1eq. HCl	5.66	25 with gentle warming

Preparing Stock Solutions for ML 204

The following data is based on the product molecular weight 226.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.42 mL	22.09 mL	44.19 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.44 mL	2.21 mL	4.42 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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Reconstitution Calculator

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References for ML 204

References are publications that support the biological activity of the product.

Miller Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 2011 PMID: 21795696
Miller Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program 2011 PMID: 22049577