ML 228

Name: ML 228
Brand: Tocris Bioscience
SKU: 4565

Tocris Bioscience, part of Bio-Techne | Catalog # 4565

COA / SDS

HIF pathway activator

Discontinued Product

4565 has been discontinued. View all HIF Activators products.

Key Product Details

Description:	HIF pathway activator
Chemical Name:	N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	415.49

View Full Technical Details for ML 228

Technical Data
Citations

Biological Activity for ML 228

ML 228 is a HIF pathway activator (EC₅₀ values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A₃ receptor, dopamine transporter, μ receptor, hERG and 5-HT_2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.

Compound Libraries for ML 228

ML 228 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 228

M. Wt	415.49
Formula	C₂₇H₂₁N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1357171-62-0
PubChem ID	46742353
InChi Key	QNRODODTMXCRKU-UHFFFAOYSA-N
Smiles	C1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ML 228

References are publications that support the biological activity of the product.

Theriault Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 2012 PMID: 22172704