ML 240

Name: ML 240
Brand: Tocris Bioscience
SKU: 5153

Tocris Bioscience, part of Bio-Techne | Catalog # 5153

Citations (3)

COA / SDS

ATP-competitive inhibitor of p97 ATPase

Key Product Details

Description:	ATP-competitive inhibitor of p97 ATPase
Chemical Name:	2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
Purity:	≥99% (HPLC)
Molecular Weight:	396.44

View Full Technical Details for ML 240

Technical Data
Citations

Biological Activity for ML 240

ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC₅₀ = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

Compound Libraries for ML 240

ML 240 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 240

M. Wt	396.44
Formula	C₂₃H₂₀N₆O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1346527-98-7
PubChem ID	49830258
InChi Key	NHAMBLRUUJAFOY-UHFFFAOYSA-N
Smiles	NC1=NC4=C(C=CC=C4)N1C3=NC2=C(OC)C=CC=C2C(NCC5=CC=CC=C5)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 240

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.93	20

Preparing Stock Solutions for ML 240

The following data is based on the product molecular weight 396.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.61 mL	63.06 mL	126.12 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
2 mM	1.26 mL	6.31 mL	12.61 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

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References for ML 240

References are publications that support the biological activity of the product.

Chou Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 2013 PMID: 23316025