ML 298 hydrochloride

Name: ML 298 hydrochloride
Brand: Tocris Bioscience
SKU: 4895

Tocris Bioscience, part of Bio-Techne | Catalog # 4895

COA / SDS

Selective PLD2 inhibitor

Discontinued Product

4895 has been discontinued. View all Phospholipase Inhibitors products.

Key Product Details

Description:	Selective PLD2 inhibitor
Chemical Name:	3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	468.9

View Full Technical Details for ML 298 hydrochloride

Technical Data
Citations

Biological Activity for ML 298 hydrochloride

ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC₅₀ values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.

Technical Data for ML 298 hydrochloride

M. Wt	468.9
Formula	C₂₂H₂₃F₃N₄O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	78243721
InChi Key	GMGMJMDCWRCPHP-UHFFFAOYSA-N
Smiles	O=C(NCCN2CCC(C(NCN3C4=CC(F)=CC=C4)=O)3CC2)C1=CC=C(F)C(F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ML 298 hydrochloride

References are publications that support the biological activity of the product.

O'Reilly Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 2013 PMID: 23445448

ML 298 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4895

Key Product Details

Biological Activity for ML 298 hydrochloride

Technical Data for ML 298 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ML 298 hydrochloride

Product Documents for ML 298 hydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

保持关注