ML 351

Name: ML 351
Brand: Tocris Bioscience
SKU: 6448

Tocris Bioscience, part of Bio-Techne | Catalog # 6448

Citations (4)

COA / SDS

Selective 12/15 LOX inhibitor; active in vivo

Key Product Details

Description:	Selective 12/15 LOX inhibitor; active in vivo
Chemical Name:	5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	249.27

View Full Technical Details for ML 351

Technical Data
Citations

Biological Activity for ML 351

ML 351 is a selective 12/15 LOX inhibitor (IC₅₀ = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

Compound Libraries for ML 351

ML 351 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 351

M. Wt	249.27
Formula	C₁₅H₁₁N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	847163-28-4
PubChem ID	664510
InChi Key	DYXYXTDIFMDJIR-UHFFFAOYSA-N
Smiles	CNC1=C(C#N)N=C(C2=CC=CC3=C2C=CC=C3)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 351

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.93	100

Preparing Stock Solutions for ML 351

The following data is based on the product molecular weight 249.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.06 mL	40.12 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for ML 351

References are publications that support the biological activity of the product.

Rai Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program 2014 PMID: 24672829
Rai Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 2014 PMID: 24684213