ML 365

Name: ML 365
Brand: Tocris Bioscience
SKU: 5337
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5337

(1)

Citations (7)

COA / SDS

Potent and selective K2P3.1 (TASK-1) channel blocker

Key Product Details

Description:	Potent and selective K_2P3.1 (TASK-1) channel blocker
Chemical Name:	2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	360.41

View Full Technical Details for ML 365

Technical Data
Citations / Reviews (1)

Biological Activity for ML 365

ML 365 is a potent and selective TASK-1 (K_2P3.1/KCNK3) channel blocker (IC₅₀ values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at K_ir2.1, voltage-gated potassium channels, KCNQ2 and K_V11.1 (hERG).

Compound Libraries for ML 365

ML 365 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 365

M. Wt	360.41
Formula	C₂₂H₂₀N₂O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	947914-18-3
PubChem ID	46785920
InChi Key	UTAJHKSGYJSZBR-UHFFFAOYSA-N
Smiles	CC1=CC=CC(C(NC2=CC(NC(C3=CC=CC=C3OC)=O)=CC=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 365

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.04	100
	ethanol	18.02	50

Preparing Stock Solutions for ML 365

The following data is based on the product molecular weight 360.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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Reconstitution Calculator

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References for ML 365

References are publications that support the biological activity of the product.

Zou ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel. Probe Reports from the NIH Molecular Libraries Program 2013 PMID: 24479195
Flaherty Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg.Med.Chem.Lett. 2014 PMID: 25017033