ML 67-33

Name: ML 67-33
Brand: Tocris Bioscience
SKU: 6886

Tocris Bioscience, part of Bio-Techne | Catalog # 6886

Citations (2)

COA / SDS

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator

Key Product Details

Chemical Name:	2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for ML 67-33

ML 67-33 is a K_2P potassium channel activator (EC₅₀ values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K_2P2.1 (TREK-1), K_2P10.1 (TREK-2) and K_2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

Technical Data for ML 67-33

Formula	C₁₈H₁₇Cl₂N₅
Storage	Store at -20°C
Purity	≥98%
CAS Number	1443290-89-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 67-33

Solubility

Soluble Soluble to 100 mM in DMSO

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References for ML 67-33

References are publications that support the biological activity of the product.

Pope et al. Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels. ACS Chem.Neurosci., 2018;9:3153 PMID: 30089357
Bagriantsev et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K_2P channels. ACS Chem.Biol., 2013;8:1841 PMID: 23738709

ML 67-33

Tocris Bioscience, part of Bio-Techne | Catalog # 6886

Key Product Details

Biological Activity for ML 67-33

Technical Data for ML 67-33

Solubility for ML 67-33

Dilution Calculator

Reconstitution Calculator

References for ML 67-33

Product Documents for ML 67-33

COA

Certificate of Analysis

SDS

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