MM 11253

Name: MM 11253
Brand: Tocris Bioscience
SKU: 3822

Tocris Bioscience, part of Bio-Techne | Catalog # 3822

Citations (22)

COA / SDS

RARγ-selective antagonist

Key Product Details

Description:	RARγ-selective antagonist
Chemical Name:	6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	462.67

View Full Technical Details for MM 11253

Technical Data
Citations

Biological Activity for MM 11253

MM 11253 is a selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.

Compound Libraries for MM 11253

MM 11253 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MM 11253

M. Wt	462.67
Formula	C₂₈H₃₀O₂S₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	345952-44-5
PubChem ID	10389639
InChi Key	DPVGXUNWCVEIGT-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=C(C5(SCCS5)C3=CC(C=CC(C(O)=O)=C4)=C4C=C3)C=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MM 11253

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.27	100

Preparing Stock Solutions for MM 11253

The following data is based on the product molecular weight 462.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.61 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for MM 11253

References are publications that support the biological activity of the product.

Le Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids. Oncogene 2000 PMID: 10723137
Dawson Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 2001 PMID: 11406543
Holmes Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J.Cell.Physiol. 2000 PMID: 10942519