MNI caged kainic acid

Name: MNI caged kainic acid
Brand: Tocris Bioscience
SKU: 2225

Tocris Bioscience, part of Bio-Techne | Catalog # 2225

Citations (1)

COA / SDS

Caged kainic acid

Discontinued Product

2225 has been discontinued. View all Caged Compounds products.

Key Product Details

Chemical Name:	(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide
Purity:	≥99%

View Full Technical Details for MNI caged kainic acid

Technical Data
Citations

Biological Activity for MNI caged kainic acid

Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Technical Data for MNI caged kainic acid

Formula	C₁₉H₂₃N₃O₆
Storage	Store at -20°C
Purity	≥99%
CAS Number	1315378-75-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MNI caged kainic acid

Solubility

Soluble Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO

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References for MNI caged kainic acid

References are publications that support the biological activity of the product.

Passlick and Ellis-Davies et al. Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods., 2017; PMID: 29051090
Palma-Cerda et al. New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology., 2012;63:624 PMID: 22609535
Maier et al. Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths., 2005;142:1 PMID: 15652611

MNI caged kainic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 2225

Key Product Details

Biological Activity for MNI caged kainic acid

Technical Data for MNI caged kainic acid

Solubility for MNI caged kainic acid

Dilution Calculator

Reconstitution Calculator

References for MNI caged kainic acid

Product Documents for MNI caged kainic acid

COA

Certificate of Analysis

SDS

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