Molnupiravir

Name: Molnupiravir
Brand: Tocris Bioscience
SKU: 7586

Tocris Bioscience, part of Bio-Techne | Catalog # 7586

Citations (1)

COA / SDS

Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection

Key Product Details

Description:	Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection
Chemical Name:	β-D-N⁴-hydroxycytidine-5'-isopropyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	329.31

View Full Technical Details for Molnupiravir

Technical Data
Citations

Biological Activity for Molnupiravir

Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N⁴-hydroxycytidine (NHC). Molnupiravir competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC₅₀ values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, Molnupiravir improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.

Technical Data for Molnupiravir

M. Wt	329.31
Formula	C₁₃H₁₉N₃O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2492423-29-5
PubChem ID	145996610
InChi Key	HTNPEHXGEKVIHG-QCNRFFRDSA-N
Smiles	CC(C(OC[C@H]1O[C@@H](N2C=CC(NO)=NC2=O)[C@@H]([C@@H]1O)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Molnupiravir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.93	100
	water	32.93	100

Preparing Stock Solutions for Molnupiravir

The following data is based on the product molecular weight 329.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.18 mL	30.37 mL
5 mM	0.61 mL	3.04 mL	6.07 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for Molnupiravir

References are publications that support the biological activity of the product.

Sheahan An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 2020 PMID: 32253226
Gordon Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. J.Biol.Chem. 2021 PMID: 33989635
Toots Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci.Transl.Med. 2019 PMID: 31645453