MRS 2500 tetraammonium salt

Name: MRS 2500 tetraammonium salt
Brand: Tocris Bioscience
SKU: 2159

Tocris Bioscience, part of Bio-Techne | Catalog # 2159

Citations (17)

COA / SDS

Highly potent and selective P2Y1 antagonist

Key Product Details

Chemical Name:	(1R,2S)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt
Purity:	≥96%
Molecular Weight:	629.29 kDa

View Full Technical Details for MRS 2500 tetraammonium salt

Technical Data
Citations

Biological Activity for MRS 2500 tetraammonium salt

MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y₁ receptor (K_i = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.

Technical Data for MRS 2500 tetraammonium salt

M. Wt	629.29 kDa
Formula	C₁₃H₁₈N₅O₈P₂I.4NH₃
Storage	Store at -20°C
Purity	≥96%
CAS Number	630103-23-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2500 tetraammonium salt

Solubility

Soluble Soluble to 20 mM in water

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References for MRS 2500 tetraammonium salt

References are publications that support the biological activity of the product.

Lu et al. Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther., 2007;323:157 PMID: 17626796
Kim et al. 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y₁ receptor antagonists. J.Med.Chem, 2003;46:4974 PMID: 14584948
Cattaneo et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y₁ receptor. Biochem.Pharmacol., 2004;68:1995 PMID: 15476670
Hechler et al. MRS2500 [2-iodo-N⁶-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y₁ receptor with strong antithrombotic activity in mice. J.Pharmacol.Exp.Ther., 2006;316:556 PMID: 16236815