MRS 2578

Name: MRS 2578
Brand: Tocris Bioscience
SKU: 2146
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2146

(2)

Citations (72)

COA / SDS

Selective P2Y6 antagonist

Key Product Details

Description:	Selective P2Y₆ antagonist
Chemical Name:	N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea
Purity:	≥95% (HPLC)
Molecular Weight:	472.66

View Full Technical Details for MRS 2578

Technical Data
Citations / Reviews (2)

Biological Activity for MRS 2578

MRS 2578 is a selective antagonist of P2Y₆ nucleotide receptors; IC₅₀ values are 37 and 98 nM at human and rat P2Y₆ receptors respectively. Displays no activity at P2Y₁, P2Y₂, P2Y₄ and P2Y₁₁ receptors (IC₅₀ > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Technical Data for MRS 2578

M. Wt	472.66
Formula	C₂₀H₂₀N₆S₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	711019-86-2
PubChem ID	16078986
InChi Key	QOHNRGHTJPFMSL-UHFFFAOYSA-N
Smiles	S=C(NCCCCNC(NC2=CC(N=C=S)=CC=C2)=S)NC1=CC(N=C=S)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2578

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.63	50

Preparing Stock Solutions for MRS 2578

The following data is based on the product molecular weight 472.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.23 mL	21.16 mL	42.31 mL
2.5 mM	0.85 mL	4.23 mL	8.46 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
25 mM	0.08 mL	0.42 mL	0.85 mL

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References for MRS 2578

References are publications that support the biological activity of the product.

Koizumi UDP acting at P2Y₆ receptors is a mediator of microglial phagocytosis. Nature 2007 PMID: 17410128
Kukulski Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J.Leukoc.Biol. 2007 PMID: 17322022
Mamedova Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y₆ nucleotide receptors. Biochem.Pharmacol. 2004 PMID: 15081875