MRS 2905

Name: MRS 2905
Brand: Tocris Bioscience
SKU: 5633

Tocris Bioscience, part of Bio-Techne | Catalog # 5633

Citations (4)

COA / SDS

Potent and selective P2Y14 receptor agonist

Key Product Details

Description:	Potent and selective P2Y₁₄ receptor agonist
Chemical Name:	2-Thiouridine-5'-O-(α, β-methylene)diphosphate trisodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	484.2

View Full Technical Details for MRS 2905

Technical Data
Citations

Biological Activity for MRS 2905

MRS 2905 is a potent and selective P2Y₁₄ receptor agonist (EC₅₀ = 0.92 nM). Exhibits >2000-fold selectivity over P2Y₆.

Technical Data for MRS 2905

M. Wt	484.2
Formula	C₁₀H₁₃N₂Na₃O₁₀P₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	121513874
InChi Key	YLWNGINRXVXFAA-ZXSRDNBLSA-K
Smiles	O[C@H]1[C@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(CP(O[Na])(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2905

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	21.79	45

Preparing Stock Solutions for MRS 2905

The following data is based on the product molecular weight 484.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.45 mM	4.59 mL	22.95 mL	45.89 mL
2.25 mM	0.92 mL	4.59 mL	9.18 mL
4.5 mM	0.46 mL	2.29 mL	4.59 mL
22.5 mM	0.09 mL	0.46 mL	0.92 mL

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References for MRS 2905

References are publications that support the biological activity of the product.

Lazarowski UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y₁₄ receptor activation. Mol.Pharmacol. 2015 PMID: 25829059
Das Human P2Y₁₄ receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 2010 PMID: 19902968