MS 275

Biological Activity for MS 275

Technical Data for MS 275

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 275

References for MS 275

References are publications that support the biological activity of the product.

• Saito et al. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc.Natl.Acad.Sci., 1999;96:4592 PMID: 10200307
• Beckers et al. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer, 2007;121:1138 PMID: 17455259
• Formisano et al. MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter. J.Pharmacol.Exp.Ther., 2015;352:236 PMID: 25467131
• Sabnis et al. Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letr. Cancer Res., 2011;71:1893 PMID: 21245100