MS 28

Name: MS 28
Brand: Tocris Bioscience
SKU: 8076

Tocris Bioscience, part of Bio-Techne | Catalog # 8076

COA / SDS

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)

Key Product Details

Description:	Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1002.25

View Full Technical Details for MS 28

Technical Data
Citations

Biological Activity for MS 28

MS 28 is a cyclinD1 Degrader (PROTAC^®) (DC₅₀ = 950 nM; D_max = 90% in vitro). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 28

M. Wt	1002.25
Formula	C₅₃H₆₇N₁₁O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229974-73-4
PubChem ID	146014438
InChi Key	MWVNDEBEHBRZEC-WWTLGBROSA-N
Smiles	O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)C(CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 28

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	100.22	100

Preparing Stock Solutions for MS 28

The following data is based on the product molecular weight 1002.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.00 mL	4.99 mL	9.98 mL
5 mM	0.20 mL	1.00 mL	2.00 mL
10 mM	0.10 mL	0.50 mL	1.00 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for MS 28

References are publications that support the biological activity of the product.

Xiong Bridged proteolysis targeting chimera (PROTAC) enables degradation of undruggable targets. J.Am.Chem.Soc. 2022 PMID: 36448571