MS 4322

Name: MS 4322
Brand: Tocris Bioscience
SKU: 8080

Tocris Bioscience, part of Bio-Techne | Catalog # 8080

COA / SDS

Selective PRMT5 Degrader (PROTAC®)

Key Product Details

Description:	Selective PRMT5 Degrader (PROTAC^®)
Chemical Name:	N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1101.33

View Full Technical Details for MS 4322

Technical Data
Citations

Biological Activity for MS 4322

MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC^®) (DC₅₀ = 1.1 μM, D_max = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC₅₀ = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand.

Technical Data for MS 4322

M. Wt	1101.33
Formula	C₅₅H₇₆N₁₀O₁₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2375432-47-4
PubChem ID	162652211
InChi Key	XUJMNOQMXWVXQE-STHBVIMFSA-N
Smiles	O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 4322

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	110.13	100

Preparing Stock Solutions for MS 4322

The following data is based on the product molecular weight 1101.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.91 mL	4.54 mL	9.08 mL
5 mM	0.18 mL	0.91 mL	1.82 mL
10 mM	0.09 mL	0.45 mL	0.91 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

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References for MS 4322

References are publications that support the biological activity of the product.

Shen Discovery of first-in-class protein arginine methyltransferase 5 (PRMT5) degraders. J.Med.Chem. 2020 PMID: 32787082