MS 6105

Name: MS 6105
Brand: Tocris Bioscience
SKU: 8073

Tocris Bioscience, part of Bio-Techne | Catalog # 8073

COA / SDS

Potent lactate dehydrogenase Degrader (PROTAC®)

Key Product Details

Description:	Potent lactate dehydrogenase Degrader (PROTAC^®)
Chemical Name:	2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	1228.6

View Full Technical Details for MS 6105

Technical Data
Citations

Biological Activity for MS 6105

MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC^®; for LDHA and LDHB respectively, DC₅₀ values are 38 nM and 74 nM; D_max is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC₅₀ range is 12.2 μM - 16.1 μM). Bioavailable in vivo.

Technical Data for MS 6105

M. Wt	1228.6
Formula	C₆₅H₈₁N₉O₉S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2891709-58-1
PubChem ID	166642429
InChi Key	APEYSKGQWJKJAZ-LCLGPXMOSA-N
Smiles	O=C([C@@H](NC(CCCCCCCCCCCC(NCCCCC#CC1=CC=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(S(N)(=O)=O)C=C4)C5=NC(C(O)=O)=CS5)=C1)=O)=O)C(C)(C)C)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 6105

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	122.86	100

Preparing Stock Solutions for MS 6105

The following data is based on the product molecular weight 1228.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.81 mL	4.07 mL	8.14 mL
5 mM	0.16 mL	0.81 mL	1.63 mL
10 mM	0.08 mL	0.41 mL	0.81 mL
50 mM	0.02 mL	0.08 mL	0.16 mL

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References for MS 6105

References are publications that support the biological activity of the product.

Sun Discovery of the first lactate dehydrogenase proteolysis targeting chimera degrader for the treatment of pancreatic cancer. J.Med.Chem. 2023 PMID: 36538511