MSC 1186

Name: MSC 1186
Brand: Tocris Bioscience
SKU: 7927

Tocris Bioscience, part of Bio-Techne | Catalog # 7927

COA / SDS

Potent and selective SRPK family inhibitor

Key Product Details

Description:	Potent and selective SRPK family inhibitor
Chemical Name:	N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	461.9

View Full Technical Details for MSC 1186

Technical Data
Citations

Biological Activity for MSC 1186

MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC₅₀ values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC₅₀ values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC₅₀ >10 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.

Technical Data for MSC 1186

M. Wt	461.9
Formula	C₁₉H₁₇ClFN₇O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2871698-23-4
PubChem ID	162368309
InChi Key	WBFJDKLBAAHKIL-UHFFFAOYSA-N
Smiles	O=S(N(C)C1=NC=CC=C1CNC2=NC(C3=NC4=C(N3)C(F)=C(Cl)C=C4)=NC=C2)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSC 1186

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.09	50

Preparing Stock Solutions for MSC 1186

The following data is based on the product molecular weight 461.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.33 mL	21.65 mL	43.30 mL
2.5 mM	0.87 mL	4.33 mL	8.66 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
25 mM	0.09 mL	0.43 mL	0.87 mL

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References for MSC 1186

References are publications that support the biological activity of the product.

Schröder MSC-1186, a highly selective pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core. J.Med.Chem. 2023 PMID: 36516476