MSC 2032964A

Name: MSC 2032964A
Brand: Tocris Bioscience
SKU: 5641

Tocris Bioscience, part of Bio-Techne | Catalog # 5641

Citations (4)

COA / SDS

Potent and selective ASK1 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective ASK1 inhibitor; orally bioavailable
Chemical Name:	N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	362.31

View Full Technical Details for MSC 2032964A

Technical Data
Citations

Biological Activity for MSC 2032964A

MSC 2032964A is a potent and selective ASK1 inhibitor (IC₅₀ = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Compound Libraries for MSC 2032964A

MSC 2032964A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MSC 2032964A

M. Wt	362.31
Formula	C₁₆H₁₃F₃N₆O
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1124381-43-6
PubChem ID	25214468
InChi Key	XUKGFHHTSUKORV-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CN=C1)NC2=NN3C(C=C(C(F)(F)F)C=C3NC4CC4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSC 2032964A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.25	20
	ethanol	3.62	10 with gentle warming

Preparing Stock Solutions for MSC 2032964A

The following data is based on the product molecular weight 362.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.80 mL	69.00 mL	138.00 mL
1 mM	2.76 mL	13.80 mL	27.60 mL
2 mM	1.38 mL	6.90 mL	13.80 mL
10 mM	0.28 mL	1.38 mL	2.76 mL

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References for MSC 2032964A

References are publications that support the biological activity of the product.

Guo Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2010 PMID: 21064192