MTK 458

Name: MTK 458
Brand: Tocris Bioscience
SKU: 7980

Tocris Bioscience, part of Bio-Techne | Catalog # 7980

Citations (5)

COA / SDS

PINK1 activator

Key Product Details

Description:	PINK1 activator
Chemical Name:	N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	332.33

View Full Technical Details for MTK 458

Technical Data
Citations

Biological Activity for MTK 458

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.

Licensing Information

Sold with kind permission of Mitokinin

Technical Data for MTK 458

M. Wt	332.33
Formula	C₁₇H₁₅F₃N₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2499962-58-0
PubChem ID	155187445
InChi Key	JOIONRWKOGDQOG-CYBMUJFWSA-N
Smiles	FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MTK 458

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.62	50
	ethanol	6.65	20

Preparing Stock Solutions for MTK 458

The following data is based on the product molecular weight 332.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.02 mL	30.09 mL	60.18 mL
2.5 mM	1.20 mL	6.02 mL	12.04 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

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References for MTK 458

References are publications that support the biological activity of the product.

Chin Pharmacological PINK1 activation ameliorates pathology in Parkinson's disease models. bioRxiv 2023 PMID: 36824886