MU 1700 trihydrochloride

Name: MU 1700 trihydrochloride
Brand: Tocris Bioscience
SKU: 8832

Tocris Bioscience, part of Bio-Techne | Catalog # 8832

COA / SDS

Potent and selective ALK1/2 inhibitor. Brain-penetrant

Key Product Details

Description:	Potent and selective ALK1/2 inhibitor. Brain-penetrant
Chemical Name:	6-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylfuro[3,2-b]pyridine trihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	515.86

View Full Technical Details for MU 1700 trihydrochloride

Technical Data
Citations

Biological Activity for MU 1700 trihydrochloride

MU 1700 trihydrochloride is a potent and selective ALK2 and ALK1 inhibitor (IC₅₀ values are 6 nM and 13 nM, respectively in biochemical assays). It is also a potent ALK6 inhibitor (IC₅₀ = 41 nM). It shows selectivity for ALK over >360 other kinases. It shows favorable pharmacokinetic for in vivo use. MU 1700 trihydrochloride is orally bioavailable. It is cell membrane permeable and brain penetrant.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1700 probe summary on the SGC website.

Technical Data for MU 1700 trihydrochloride

M. Wt	515.86
Formula	C₂₆H₂₂N₄O.3HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	RRVVHPUANQAUJY-UHFFFAOYSA-N
Smiles	C12=C(C=CC=C2)N=CC=C1C3=COC4=C3N=CC(C5=CC=C(C=C5)N6CCNCC6)=C4.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MU 1700 trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.16	10
	water	25.79	50

Preparing Stock Solutions for MU 1700 trihydrochloride

The following data is based on the product molecular weight 515.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.88 mL	19.39 mL	38.77 mL
2.5 mM	0.78 mL	3.88 mL	7.75 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References for MU 1700 trihydrochloride

References are publications that support the biological activity of the product.

Němec Discovery of two highly selective structurally orthogonal chemical probes for activin receptor-like kinases 1 and 2. J.Med.Chem. 2024 PMID: 39023313