MU 1742

Name: MU 1742
Brand: Tocris Bioscience
SKU: 7979

Tocris Bioscience, part of Bio-Techne | Catalog # 7979

Citations (1)

COA / SDS

Potent and selective CK1α, CK1δ and CK1ε inhibitor

Key Product Details

Description:	Potent and selective CK1α, CK1δ and CK1ε inhibitor
Chemical Name:	4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	408.46

View Full Technical Details for MU 1742

Technical Data
Citations

Biological Activity for MU 1742

MU 1742 is a potent and selective casein kinase 1α (CK1α), CK1δ and CK1ε inhibitor (IC₅₀values are 6, 7 and 28 nM for CK1δ, CK1α and CK1ε respectively). In vivo, MU 1742 inhibits CK1δ/ε-dependent DVL3 phosphorylation in mouse lung tissue. MU 1742 is orally bioavailable.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1742 probe summary on the SGC website.

Technical Data for MU 1742

M. Wt	408.46
Formula	C₂₂H₂₂F₂N₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	167312208
InChi Key	SWOIFXHMBKFCRM-UHFFFAOYSA-N
Smiles	FC1=CN=C(C=C1)C2=C(C3=CC=NC4=C3C=CN4)N(CC5(F)CCN(C)CC5)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MU 1742

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.85	100
	ethanol	40.85	100

Preparing Stock Solutions for MU 1742

The following data is based on the product molecular weight 408.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for MU 1742

References are publications that support the biological activity of the product.

Němec Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity. Angew.Chem.Int.Ed.Engl. 2023 PMID: 36625768