NAD 299 hydrochloride

Name: NAD 299 hydrochloride
Brand: Tocris Bioscience
SKU: 3282

Tocris Bioscience, part of Bio-Techne | Catalog # 3282

Citations (5)

COA / SDS

Selective, high affinity 5-HT1A antagonist

Key Product Details

Description:	Selective, high affinity 5-HT_1A antagonist
Chemical Name:	(3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	354.85

View Full Technical Details for NAD 299 hydrochloride

Technical Data
Citations

Biological Activity for NAD 299 hydrochloride

NAD 299 hydrochloride is a selective, high affinity 5-HT_1A receptor antagonist (K_i = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries for NAD 299 hydrochloride

NAD 299 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NAD 299 hydrochloride

M. Wt	354.85
Formula	C₁₈H₂₃FN₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	184674-99-5
PubChem ID	90488823
InChi Key	GSZJANKLCPHEEX-BTQNPOSSSA-N
Smiles	FC1=C2C(C[C@@H](N(C4CCC4)C3CCC3)CO2)=C(C(N)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NAD 299 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.48	100
	DMSO	35.48	100

Preparing Stock Solutions for NAD 299 hydrochloride

The following data is based on the product molecular weight 354.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.09 mL	28.18 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for NAD 299 hydrochloride

References are publications that support the biological activity of the product.

Arborelius The 5-HT_1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur.J.Pharmacol. 1999 PMID: 10528148
Johansson The pharmacological characterization of a novel selective 5-hydroxytryptamine-_1A receptor antagonist, NAD-299. J.Pharmacol.Exp.Ther. 1997 PMID: 9336327
Larsson Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT_1A receptor antagonists. Eur.J.Pharmacol. 1998 PMID: 9652362